Family data support a dominant major gene for Tourette syndrome.

@article{Price1988FamilyDS,
  title={Family data support a dominant major gene for Tourette syndrome.},
  author={Robert A. Price and David L. Pauls and Stephan Kruger and Eric D Caine},
  journal={Psychiatry research},
  year={1988},
  volume={24 3},
  pages={
          251-61
        }
}
A dominant major gene was supported by analyses of 50 large extended Tourette syndrome (TS) pedigrees and by a subset of families defined by proband's clinical response to the neuroleptic drug haloperidol. Relatives were defined as affected if they ever had tics or TS. Assuming a nearly even sex ratio for TS and related symptoms resulted in the best fit of the genetic model to observed rates in families. 

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…