Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences.

@article{Floros2001FamilybasedTD,
  title={Family-based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences.},
  author={Joanna Floros and Ruzong Fan and Antony Matthews and Susan L. Diangelo and Juan Luo and Heber C Nielsen and Martin L. Dunn and Ira H. Gewolb and Janna G. Koppe and Loekie van Sonderen and L Farri-Kostopoulos and M Tzaki and Mika R{\"a}met and Jennifer D Merrill},
  journal={Clinical genetics},
  year={2001},
  volume={60 3},
  pages={
          178-87
        }
}
A key cause of respiratory distress syndrome (RDS) in the prematurely born infant is deficiency of pulmonary surfactant, a lipoprotein complex. Both low levels of surfactant protein A (SP-A) and SP-A alleles have been associated with RDS. Using the candidate gene approach, we performed family-based linkage studies to discern linkage of SP-A to RDS and identify SP-A susceptibility or protective alleles. Moreover, we performed case-control studies of whites and blacks to detect association… CONTINUE READING
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