Family-based genome-wide association study in Patagonia confirms the association of the DMD locus and cleft lip and palate.

@article{Fonseca2015FamilybasedGA,
  title={Family-based genome-wide association study in Patagonia confirms the association of the DMD locus and cleft lip and palate.},
  author={Renata Fragelli Fonseca and Fl{\'a}via M de Carvalho and Fernando Adri{\'a}n Poletta and David Montaner and Joaqu{\'i}n Dopazo and Juan C. Mereb and Miguel {\^A}ngelo Martins Moreira and H{\'e}ctor N Seu{\'a}nez and Alexandre R Vieira and Eduardo Enrique Castilla and I{\^e}da M Orioli},
  journal={European journal of oral sciences},
  year={2015},
  volume={123 5},
  pages={
          381-384
        }
}
The etiology of cleft lip with or without cleft palate (CL±P) is complex and heterogeneous, and multiple genetic and environmental factors are involved. Some candidate genes reported to be associated with oral clefts are located on the X chromosome. At least three genes causing X-linked syndromes [midline 1 (MID1), oral-facial-digital syndrome 1 (OFD1), and dystrophin (DMD)] were previously found to be associated with isolated CL±P. We attempted to confirm the role of X-linked genes in the… CONTINUE READING
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