Family-based association tests using genotype data with uncertainty.

@article{Yu2012FamilybasedAT,
  title={Family-based association tests using genotype data with uncertainty.},
  author={Zhaoxia Yu},
  journal={Biostatistics},
  year={2012},
  volume={13 2},
  pages={228-40}
}
Family-based association studies have been widely used to identify association between diseases and genetic markers. It is known that genotyping uncertainty is inherent in both directly genotyped or sequenced DNA variations and imputed data in silico. The uncertainty can lead to genotyping errors and missingness and can negatively impact the power and Type I error rates of family-based association studies even if the uncertainty is independent of disease status. Compared with studies using… CONTINUE READING

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