Family-based association study of synapsin II and schizophrenia.

  title={Family-based association study of synapsin II and schizophrenia.},
  author={Qi Chen and Guang He and Wei Qin and Qing-ying Chen and Xin-zhi Zhao and Shi-wei Duan and Xinmin Liu and Guo-yin Feng and Yi-feng Xu and David St Clair and Min Li and Jin-huan Wang and Yang-ling Xing and Jian-Guo Shi and Lin He},
  journal={American journal of human genetics},
  volume={75 5},
Synapsin II has been proposed as a candidate gene for vulnerability to schizophrenia on the basis of its function and its location in a region of the genome implicated by linkage studies in families with schizophrenia. We recently reported positive association of synapsin II with schizophrenia in a case-control study (Chen et al. 2004). However, since case-control analyses can generate false-positive results in the presence of minor degrees of population stratification, we have performed a… CONTINUE READING

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