Family-based association study of Neuregulin 1 with psychotic bipolar disorder.

  title={Family-based association study of Neuregulin 1 with psychotic bipolar disorder.},
  author={Fernando S. Goes and Virginia L. Willour and Peter P. Zandi and Pamela L Belmonte and Dean F Mackinnon and Francis M. Mondimore and Barbara A. Schweizer and Elliot S. Gershon and Francis J. McMahon and James B. Potash},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={150B 5},
The Neuregulin 1 gene (NRG1) has been associated with schizophrenia, and, to a lesser extent, with bipolar disorder (BP). We investigated the association of NRG1 with BP in a large family sample, and then performed analyses according to the presence of psychotic features or mood-incongruent psychotic features. We genotyped 116 tagSNPs and four Icelandic "core" SNPs in 1,199 subjects from 314 nuclear families. Of 515 BP offspring, 341 had psychotic features, and 103 had mood-incongruent… CONTINUE READING


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