Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

  title={Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus},
  author={Pamela Sklar and Stacey Bolk Gabriel and Melvin G. McInnis and Phil Bennett and Y -M Lim and Grace L. Tsan and Stephen Ansolabehere Brian Schaffner and George Kirov and Ian Jones and MichaelJ. Owen and Nicholas John Craddock and J Raymond Depaulo and Eric S. Lander},
  journal={Molecular Psychiatry},
Identification of the genetic bases for bipolar disorder remains a challenge for the understanding of this disease. Association between 76 candidate genes and bipolar disorder was tested by genotyping 90 single-nucleotide polymorphisms (SNPs) in these genes in 136 parent-proband trios. In this preliminary analysis, SNPs in two genes, brain-derived neurotrophic factor (BDNF) and the alpha subunit of the voltage-dependent calcium channel were associated with bipolar disorder at the P<0.05 level… CONTINUE READING
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