Family-based association studies.

@article{Zhao2000FamilybasedAS,
  title={Family-based association studies.},
  author={Hongyu Zhao},
  journal={Statistical methods in medical research},
  year={2000},
  volume={9 6},
  pages={563-87}
}
  • Hongyu Zhao
  • Published 2000 in Statistical methods in medical research
Over the past decade, attention has turned from positional cloning of Mendelian disease genes to the dissection of complex diseases. Both theoretical and empirical studies have shown that traditional linkage studies may be inferior in power compared to studies that directly utilize allele status. Case-control association studies, as an alternative, are subject to bias due to population stratification. As a compromise between linkage studies and case-control studies, family-based association… CONTINUE READING

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