Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia.

@article{Barbier2008FamilybasedAO,
  title={Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia.},
  author={Mathieu Barbier and Nicolas Fr{\'e}d{\'e}ric Delahaye and Francis Fumoux and Pascal Rihet},
  journal={Microbes and infection},
  year={2008},
  volume={10 6},
  pages={673-9}
}
Tumor necrosis factor (TNF)-related genes are thought to play a role in human malaria. TNF polymorphisms have been associated with severe malaria, mild malaria, and parasitemia. Lymphotoxin-alpha gene (LTA) that belongs to the TNF family is one such candidate gene. Here we report the family-based association analysis of a cis-regulatory lymphotoxin-alpha polymorphism with parasitemia in two independent populations living in Burkina Faso. Analysis of 199 subjects (34 families) living in an urban… CONTINUE READING

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