Family-based association of FKBP5 in bipolar disorder

  title={Family-based association of FKBP5 in bipolar disorder},
  author={Virginia L. Willour and Huiqian Chen and Jennifer Toolan and Pamela L Belmonte and David J. Cutler and Fernando S. Goes and Peter P. Zandi and Rebecca S Y Lee and Dean F Mackinnon and Francis M. Mondimore and Barbara A. Schweizer and J Raymond Depaulo and Elliot S. Gershon and Francis J. McMahon and James B. Potash},
  journal={Molecular Psychiatry},
The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and with rapid response to antidepressant treatment. We sought to determine whether common FKBP5 variants confer risk for bipolar disorder. We genotyped seven tag single-nucleotide polymorphisms (SNPs) in FKBP5, plus two SNPs previously associated with illness, in 317 families with 554… CONTINUE READING


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Manic-Depressive Illness, Second Edition

FK Goodwin, KR Jamison

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EF van Rossum, EB Binder, +3 authors S Modell
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