Family-based association analysis with tightly linked markers.

  title={Family-based association analysis with tightly linked markers.},
  author={Michael Knapp and Tim Becker},
  journal={Human heredity},
  volume={56 1-3},
Refining genomic regions which have been identified by linkage analysis to contain a disease susceptibility locus has proven to be a challenging task. Detecting association between the disease and a genetic marker can significantly narrow down the candidate region. Since an adequate sample of families is already available from the genome scan, family-based… CONTINUE READING