Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.

@article{Dick2007FamilybasedAA,
  title={Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.},
  author={Danielle M Dick and Jen Chyong Wang and Jevon Plunkett and Fazil Aliev and Anthony L. Hinrichs and Sarah E Bertelsen and John P. Budde and Elianna L Goldstein and Daniel Kaplan and Howard J. Edenberg and John J I Nurnberger and Victor M. Hesselbrock and Marc A Schuckit and Sam Kuperman and Jay A. Tischfield and Bernice Porjesz and H. Begleiter and Laura J. Bierut and Alison M. Goate},
  journal={Alcoholism, clinical and experimental research},
  year={2007},
  volume={31 10},
  pages={1645-53}
}
BACKGROUND There is an extensive and inconsistent literature on the association of the dopamine D2 receptor gene (DRD2) with alcohol dependence. Conflicting results have been attributed to differences in the severity of the alcohol dependence phenotype across studies, failure to exclude related disorders from comparison groups, and artifacts of population-stratification. Recently the genetic polymorphism most widely analyzed in DRD2, Taq1A, has been discovered to reside in a neighboring gene… CONTINUE READING