Family-based analysis of MSX1 haplotypes for association with oral clefts.

@article{Fallin2003FamilybasedAO,
  title={Family-based analysis of MSX1 haplotypes for association with oral clefts.},
  author={M Daniele Fallin and Jacqueline B. Hetmanski and Jiwan Park and Alan F. Scott and Roxann Ingersoll and Hans A. Fuernkranz and Iain Mcintosh and Terri H. Beaty},
  journal={Genetic epidemiology},
  year={2003},
  volume={25 2},
  pages={
          168-75
        }
}
Oral clefts, one of the most common forms of birth defects, are considered to be of complex etiology, including both genetic and environmental causes. To date, however, no particular genetic cause has been confirmed for isolated, nonsyndromic oral clefts. Previous case-control and family-based association studies reported an association between an intronic CA repeat of the MSX1 gene and risk for oral clefts. In this study, we identify eight single-nucleotide polymorphisms (SNPs) in the MSX1… CONTINUE READING
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