Family and twin studies in systemic lupus erythematosus.

@article{Grennan1997FamilyAT,
  title={Family and twin studies in systemic lupus erythematosus.},
  author={David Michael Grennan and Andrew Parfitt and Nicholas Manolios and Qiusheng Huang and Valentine J. Hyland and Heather Dunckley and Tim Doran and Paul Gatenby and Charles Badcock},
  journal={Disease markers},
  year={1997},
  volume={13 2},
  pages={93-8}
}
We have estimated how much of the total genetic predisposition to SLE may be attributable to genes outside the HLA region by comparing figures for concordance of SLE in monozygotic twins with those for concordance in HLA identical siblings in Australia. None of six dizygotic co-twins of white Australian SLE probands was concordant for SLE. One of four (25%) monozygotic co-twins of white Australian SLE probands was concordant for SLE which when added to previously published figures for Caucasoid… CONTINUE READING

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