Family-Based Multi-SNP X Chromosome Analysis Using Parent Information

@article{Wise2016FamilyBasedMX,
  title={Family-Based Multi-SNP X Chromosome Analysis Using Parent Information},
  author={A. Wise and M. Shi and C. Weinberg},
  journal={Frontiers in Genetics},
  year={2016},
  volume={7}
}
  • A. Wise, M. Shi, C. Weinberg
  • Published 2016
  • Medicine, Biology
  • Frontiers in Genetics
  • We propose a method for association analysis of haplotypes on the X chromosome that offers both improved power and robustness to population stratification in studies of affected offspring and their parents if all three have been genotyped. The method makes use of assumed parental haplotype exchangeability (PHE), a weaker assumption than Hardy-Weinberg equilibrium (HWE). PHE requires that in the source population, of the three X chromosome haplotypes carried by the two parents, each is equally… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 25 REFERENCES
    Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families.
    40
    X-APL: an improved family-based test of association in the presence of linkage for the X chromosome.
    24
    Learning about the X from our parents
    5
    Likelihood-Based Inference on Haplotype Effects in Genetic Association Studies
    154
    Haplotypes vs single marker linkage disequilibrium tests: what do we gain?
    432
    Likelihood-Based Association Analysis for Nuclear Families and Unrelated Subjects with Missing Genotype Data
    616
    Making the most of case-mother/control-mother studies.
    47
    Using Case‐parent Triads to Estimate Relative Risks Associated with a Candidate Haplotype
    8