Family-Based Multi-SNP X Chromosome Analysis Using Parent Information

  title={Family-Based Multi-SNP X Chromosome Analysis Using Parent Information},
  author={A. S. Wise and Min Shi and Clarice R. Weinberg},
  booktitle={Front. Genet.},
We propose a method for association analysis of haplotypes on the X chromosome that offers both improved power and robustness to population stratification in studies of affected offspring and their parents if all three have been genotyped. The method makes use of assumed parental haplotype exchangeability (PHE), a weaker assumption than Hardy-Weinberg equilibrium (HWE). PHE requires that in the source population, of the three X chromosome haplotypes carried by the two parents, each is equally… CONTINUE READING