• DOI:10.1002/ajmg.b.30203
• Corpus ID: 29561540

Family‐based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: No evidence for association in UK and Taiwanese samples

@article{Xu2005FamilybasedAS,
  title={Family‐based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: No evidence for association in UK and Taiwanese samples},
  author={Xiaohui Xu and Jonathan Mill and Chi-Ken Chen and Keeley J. Brookes and Eric Taylor and Philip Asherson},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2005},
  volume={139B}
}

• Xiaohui Xu, J. Mill, +3 authors P. Asherson
• Published 5 November 2005
• Biology
• American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Five independent studies have reported associations between serotonin transporter gene (5‐HTT) polymorphisms and attention deficit hyperactivity disorder (ADHD). Four studies found evidence for association between the long‐allele of a 44‐base pair insertion/deletion polymorphism (5‐HTTLPR), one of the studies found association to a variable number tandem repeat within intron 2, another to the T‐allele of a single base pair substitution in the 3′‐untranslated regions and another reported preferential transmission of a haplotype of the three markers (long‐allele/10‐repeat‐allele/T‐allele). One further study found no evidence for these associations. We investigated the association of these three markers in two samples of ADHD patients from the United Kingdom (n = 197) and Taiwan (n = 212), using within‐family tests of association. No association was found between any of the three markers in either of the two populations. Although we found some evidence for the preferential transmission of a rare haplotype (long‐allele/9‐repeat‐allele/T‐allele; χ2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone. © 2005 Wiley‐Liss, Inc.