Familial unconjugated hyperbilirubinemia syndromes.

  title={Familial unconjugated hyperbilirubinemia syndromes.},
  author={Juerg Reichen},
  journal={Seminars in liver disease},
  volume={3 1},
Our understanding of the biochemical defects underlying the hepatic forms of congenital, unconjugated hyperbilirubinemias has been greatly enhanced over the past decade. This is mostly due to the availability of pure, labeled bilirubin, the appropriate kinetic analyses, and a better understanding of the mechanisms underlying bilirubin conjugation. Although it is quite obvious that the defect underlying Gilbert's and Crigler-Najjar syndromes is deficient glucuronidation, the molecular… CONTINUE READING


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