Familial thyroxine-binding globulin deficiency in a patient with congenital hypothyroidism.


A kindred with deficiency of thyroxine binding globulin (TBG) was presented. The propositus, a 1-year old female also had congenital hypothyroidism with ectopic (sublingual) thyroid. Decrease in TBG-binding capacity (TBG) values ranging from 1.2-10.2 mug/100 ml) was detected in the seven relatives on the maternal side. Of these subject 2 were male and 5… (More)