Familial thrombocytopenia associated with platelet autoantibodies and chromosome breakage

@article{Helmerhorst1984FamilialTA,
  title={Familial thrombocytopenia associated with platelet autoantibodies and chromosome breakage},
  author={Frans M. Helmerhorst and David C. Heaton and Peter E. Crossen and Albert E. G. Kr. von dem Borne and C. P. Engelfriet and Adayapalam Tyagarajan Natarajan},
  journal={Human Genetics},
  year={1984},
  volume={65},
  pages={252-256}
}
An extended family is described in which three members had thrombocytopenia. These affected members had chromosomal changes resembling those found in Fanconi's anaemia, though they lacked the development defects associated with that syndrome. One had bone-marrow hypoplasia and died of squamous cell carcinoma of the mouth at the age of 27. In addition, all… CONTINUE READING