Familial sarcoma: challenging pedigrees.

  title={Familial sarcoma: challenging pedigrees.},
  author={Henry T. Lynch and Carolyn Deters and David Hogg and Jane F. Lynch and Yulia Kinarsky and Zoran Gatalica},
  volume={98 9},
BACKGROUND Partially due to the rare occurrence of soft tissue and osteogenic sarcomas in the general population, scant attention has been given to their hereditary etiology. Their overall poor prognosis might be ameliorated through an understanding of their environmental and hereditary causal factors, and/or their interactions, thereby contributing to earlier diagnosis and even the development of molecularly based targeted therapy. METHODS The authors selected 10 sarcoma-prone families from… CONTINUE READING


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