Familial risks of cancer as a guide to gene identification and mode of inheritance.

@article{Hemminki2004FamilialRO,
  title={Familial risks of cancer as a guide to gene identification and mode of inheritance.},
  author={Kari Hemminki and Xinjun Li},
  journal={International journal of cancer},
  year={2004},
  volume={110 2},
  pages={291-4}
}
Occurrence of cancer in parents and offspring may be due to dominant causes, whereas cancer affecting only siblings may indicate a recessive causation. Systematic comparisons of mode of inheritance have not been available for most types of cancer. Using the Swedish Family-Cancer Database, standardized incidence ratios (SIR) were calculated for offspring whose parents or siblings were diagnosed with the same cancer. The degree of environmental causation was assessed by spouse correlation and by… CONTINUE READING
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