Familial risks for common diseases: etiologic clues and guidance to gene identification.

  title={Familial risks for common diseases: etiologic clues and guidance to gene identification.},
  author={Kari Hemminki and Xinjun Li and Kristina Sundquist and Jan Sundquist},
  journal={Mutation research},
  volume={658 3},
Familial clustering of a disease is a direct indicator of a possible heritable cause, provided that environmental sharing can be excluded. If the familial clustering is lacking, the likelihood of a heritable influence is also small. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the genome scan. The availability of a Multigeneration Register in Sweden provides a reliable access to families throughout the last… CONTINUE READING


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