Familial renal oncocytoma: clinicopathological study of 5 families.

@article{Weirich1998FamilialRO,
  title={Familial renal oncocytoma: clinicopathological study of 5 families.},
  author={Gregor Weirich and Gladys M. Glenn and Klaus Junker and Mar{\'i}a Merino and Stephan St{\"o}rkel and Irina A. Lubensky and Peter L. Choyke and Svetlana D Pack and Mahul B. Amin and M. M. Walther and W. Marston Linehan and Berton Zbar},
  journal={The Journal of urology},
  year={1998},
  volume={160 2},
  pages={
          335-40
        }
}
Familial and Sporadic Renal Oncocytomas – A Comparative Molecular–Genetic Analysis
TLDR
It is demonstrated that partial or complete loss of chromosome 1 is the most common alteration in renal oncocytomas, sporadic and familial, however, chromosome changes are much rarer in familial than in sporadic renal onoceletomas.
The genetics of renal oncocytosis: a possible model for neoplastic progression.
Renal oncocytosis: a morphologic study of fourteen cases.
TLDR
The association of numerous renal oncocytoma-like nodules with lesions having a mixed morphology or a morphology of pure chromophobe renal cell carcinoma suggests that they may constitute a morphologic spectrum of onCocytic tumors and that renal on cocytomas and chromophobes may arise from a common progenitor lesion.
Renal Oncocytosis Presenting in Childhood: A Case Report
TLDR
This case in a 12-year-old girl is remarkable for its heterogeneous tumor morphology, with some areas containing chromophobe carcinoma-like cells, and pathologists are cautioned in making a malignant diagnosis in such cases, especially in younger patients.
Familial adult renal neoplasia
TLDR
A genetic approach to managing familial cases of renal tumours occasionally encountered by cancer geneticists and urologists is discussed.
Bilateral multifocal renal oncocytoma
TLDR
A 12-year-old girl who presented with massive left renomegaly and who was found to have bilateral cystic kidneys and a diagnosis of multifocal oncocytoma was made after detailed histological examination.
[Hereditary renal tumors: More common than expected?].
TLDR
The recognition of patients with hereditary renal cell carcinoma and the identification of individual family members with a higher risk of development of renal tumors is important for early tumor detection and treatment.
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References

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Renal oncocytoma : A reappraisal of morphologic features with clinicopathologic findings in 80 cases
TLDR
Renal oncocytoma is a benign neoplasm and therefore does not merit a nuclear grading scheme, and has unique histologic features including an organoid and tubulocystic architecture, myxoid or hyalinized stroma, and occasionally some atypical findings including nuclear pleomorphism.
Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors.
TLDR
The light and electron microscopic morphology of two renal parenchymal tumors was consistent with the diagnosis of renal oncocytoma and Restriction analysis of the mitochondrial DNA revealed a new autoradiographic band at about 50 basepairs in size occurring exclusively in onCocytomas.
Comparative genomic hybridization for genetic analysis of renal oncocytomas
TLDR
The purpose of the present study was to identify the genetic alterations associated with the development of renal oncocytomas by using comparative genomic hybridization, and to identify loss of genetic material from chromosomes 1 and/or 14 in six of these tumors.
Renal oncocytoma: a clinicopathologic study of 70 cases.
TLDR
It is concluded that renal oncocytomas have a varied morphologic appearance and their pathologic diagnosis should be based on a constellation of architectural and cytologic features.
Cytogenetic abnormalities in renal oncocytic neoplasms
TLDR
In four cases and in the cases previously reported, loss of a sex chromosome, abnormalities of chromosomes 1 and 22, and trisomy 12 are findings most often observed in renal oncocytoma.
Bilateral multiple renal oncocytomas and cysts associated with a constitutional translocation (8;9)(q24.1;q34.3) and a rare constitutional VHL missense substitution
TLDR
Cytogenetic analysis of the patient's lymphocytes revealed a constitutional 46,XY,add (9)(q34.3) karyotype, which strengthened the molecular diagnosis of oncocytoma and a previously unreported germline missense substitution, Pro40Arg, in exon 1 of the VHL gene was also found, adding to the complexity of the genetic profile.
Inherited carcinomas of the kidney.
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