Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.

@article{Pathak1982FamilialRC,
  title={Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.},
  author={Sen Pathak and Leonell C. Strong and Robert E. Ferrell and Andreia Trindade},
  journal={Science},
  year={1982},
  volume={217 4563},
  pages={939-41}
}
Cytogenic studies were performed on the direct chromosome preparations of the renal cell carcinoma cells and the cultured peripheral blood lymphocytes of a patient with familial renal cell carcinoma. The results revealed a specific, acquired translocations (3p;11p) present in the majority of metaphases of the tumor, indicating that the development of renal cell carcinoma is associated with a deletion in the proximal end of 3p. Renal cell carcinoma is thus the third example--the first two being… CONTINUE READING

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