Familial recurrence-pattern analysis of nonsyndromic isolated cleft palate--a Danish Registry study.

@article{Christensen1996FamilialRA,
  title={Familial recurrence-pattern analysis of nonsyndromic isolated cleft palate--a Danish Registry study.},
  author={Kaare Christensen and Laura E. Mitchell},
  journal={American journal of human genetics},
  year={1996},
  volume={58 1},
  pages={182-90}
}
The finding of an association between genetic variation at the transforming growth-factor alpha (TGFA) locus and nonsyndromic isolated cleft palate (CP) represents a potentially important breakthrough in our understanding of this condition. The present study was undertaken to assess the feasibility of detecting linkage to putative CP-susceptibility loci, such as TGFA. To this end, the familial recurrence pattern for CP was evaluated to determine the most likely mode of inheritance for this… CONTINUE READING