Familial predisposition to renal disease in two generations of Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus

@article{Pettitt1990FamilialPT,
  title={Familial predisposition to renal disease in two generations of Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus},
  author={David J. Pettitt and Mohammed F. Saad and Peter H. Bennett and Robert G Nelson and William C. Knowler},
  journal={Diabetologia},
  year={1990},
  volume={33},
  pages={438-443}
}
We studied the occurrence of renal disease by measuring serum creatinine and urine protein concentrations in the diabetic members of 316 Pima Indian families with Type 2 (non-insulin-dependent) diabetes in two successive generations to determine if diabetic renal disease aggregates in families. After adjustment for sex and other risk factors, proteinuria occurred among 14.3% of the diabetic offspring if neither parent had proteinuria, 22.9% if at least one diabetic parent had proteinuria, and… CONTINUE READING

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