Familial occurrence of the antiphospholipid syndrome.

  title={Familial occurrence of the antiphospholipid syndrome.},
  author={Francis Matthey and Kieran M J Walshe and Ian Mackie and Samuel J. Machin},
  journal={Journal of clinical pathology},
  volume={42 5},
In a family of four the whole spectrum of antiphospholipid and associated antibodies was present but without evidence of connective tissue disease. All four members had anticardiolipin antibodies; two had a confirmed lupus anticoagulant. Thrombocytopenia was severe in one and associated with a high titre of antiplatelet antibody, while another member was found to have a positive antiglobulin test. One member also had a low protein C concentration while two had decreased concentration of protein… CONTINUE READING
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