Familial non-specific dementia maps to chromosome 3.

  title={Familial non-specific dementia maps to chromosome 3.},
  author={J. Lesley Brown and Alan Ashworth and Susanne Gydesen and Asger Sorensen and Martin Rossor and John S. Hardy and John Collinge},
  journal={Human molecular genetics},
  volume={4 9},
A significant minority of degenerative dementias lack distinctive inclusion bodies, plagues or tangles on pathological examination. Half of these cases have a positive family history of dementia. We have studied the largest published family with such a dementia and mapped the disease locus to a 12 cM region of chromosome 3 spanning the centromere. Haplotype analysis demonstrates a common region shared between all affected individuals between the markers D3S1284 and D3S1603. Like a number of… CONTINUE READING


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