Familial non-medullary thyroid cancer: unraveling the genetic maze.

  title={Familial non-medullary thyroid cancer: unraveling the genetic maze.},
  author={Samantha Peiling Yang and Joanne Ngeow},
  journal={Endocrine-related cancer},
  volume={23 12},
Familial non-medullary thyroid cancer (FNMTC) constitutes 3-9% of all thyroid cancers. Out of all FNMTC cases, only 5% in the syndromic form has well-studied driver germline mutations. These associated syndromes include Cowden syndrome, familial adenomatous polyposis, Gardner syndrome, Carney complex type 1, Werner syndrome and DICER1 syndrome. It is important for the clinician to recognize these phenotypes so that genetic counseling and testing can be initiated to enable surveillance for… CONTINUE READING


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