Familial neuromyelitis optica.

  title={Familial neuromyelitis optica.},
  author={Marcelo Matiello and Hyo Jung Kim and W C Kim and Doralina Guimar{\~a}es Brum and Amilton Antunes Barreira and Daniel J. Kingsbury and Gordon T. Plant and Tarso Adoni and Brian G. Weinshenker},
  volume={75 4},
BACKGROUND Detection of aquaporin-4-specific immunoglobulin G (IgG) has expanded the spectrum of neuromyelitis optica (NMO). Rare reports of familial aggregation have suggested a component of genetic susceptibility but these reports mostly antedated the discovery of the NMO-IgG biomarker and recently updated diagnostic criteria. METHODS We report a case series describing the demographic, clinical, neuroimaging, and NMO-IgG serologic status of 12 multiplex NMO pedigrees with a total of 25… CONTINUE READING


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