Familial leukemia. HLA system and leukemia predisposition in a family.


Four cases of acute lymphocytic leukemia occurred in a family comprising 30 members. Genetic and cytogenetic studies showed a possible linkage between an HLA haplotype and the leukemia predisposition that was suggested by site-directed chromosome rearrangements in cultured skin fibroblasts. The possession of genetic markers, other than HLA types, could not… (More)


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