Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.

@article{Gruver1999FamilialHC,
  title={Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.},
  author={E J Gruver and Diane Fatkin and Grant Dodds and Joseph Kisslo and Barry Joel Maron and Jonathan G Seidman and Christine E Seidman},
  journal={The American journal of cardiology},
  year={1999},
  volume={83 12A},
  pages={13H-18H}
}
More than 40 different beta-cardiac myosin heavy chain (beta-MHC) missense mutations have been identified that cause familial hypertrophic cardiomyopathy (FHC). Some of these are recognized to have important clinical manifestations, such as an increased incidence of sudden death. We report that the beta-MHC missense mutation Arg663His causes predominant cardiac morphology and atrial fibrillation. Longitudinal clinical evaluations were performed in a kindred with FHC. The nucleotide sequence of… CONTINUE READING