Familial hypertrophic cardiomyopathy: functional effects of myosin mutation R723G in cardiomyocytes.

@article{Kraft2013FamilialHC,
  title={Familial hypertrophic cardiomyopathy: functional effects of myosin mutation R723G in cardiomyocytes.},
  author={Theresia Kraft and E. Rosalie Witjas-Paalberends and Nicky M. Boontje and Snigdha Tripathi and Almuth Brandis and Judith Montag and Julie L. Hodgkinson and Antonio Francino and Francisco Navarro-L{\'o}pez and Bernhard Brenner and Ger J M Stienen and Jolanda van der Velden},
  journal={Journal of molecular and cellular cardiology},
  year={2013},
  volume={57},
  pages={
          13-22
        }
}
Familial Hypertrophic Cardiomyopathy (FHC) is frequently caused by mutations in the β-cardiac myosin heavy chain (β-MyHC). To identify changes in sarcomeric function triggered by such mutations, distinguishing mutation effects from other functional alterations of the myocardium is essential. We previously identified a direct effect of mutation R723G (MyHC723) on myosin function in slow Musculus soleus fibers. Here we investigate contractile features of left ventricular cardiomyocytes of FHC… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES