Familial hypercholesterolemia in children

@article{Rodenburg2004FamilialHI,
  title={Familial hypercholesterolemia in children},
  author={Jessica Rodenburg and M. N. Vissers and Albert Wiegman and Mieke D. Trip and HD Bakker and John J. P. Kastelein},
  journal={Current Opinion in Lipidology},
  year={2004},
  volume={15},
  pages={405-411}
}
Purpose of this review This review provides an update on recent advances in the diagnosis and management of children with familial hypercholesterolemia. Recent findings A large cross-sectional cohort study of paediatric familial hypercholesterolemia demonstrated that affected children had a 5-fold more rapid increase of carotid arterial wall intima-media thickness during childhood years than their affected siblings. This faster progression led to a significant deviation in terms of intima-media… 
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47 Citations
Background Citations
12
Results Citations
1

47 Citations

Clinical management of familial hypercholesterolemia: new insights from international guidelines and recent studies
TLDR
Current, let alone future, therapies are extremely effective in reducing both LDL-C and CVD events in patients with FH, which should be a feature of preventative CVD medicine programmes.
Familial hypercholesterolemia in childhood
TLDR
The present study shows a clear reduction of LDL-C by plant sterolss therapy, however, short-term plant sterols therapy does not improve the endotheliall function in FH children.
Familial hypercholesterolaemia in children and adolescents: A new paediatric model of care
TLDR
A new paediatric model of care for FH is described, which combines Cascade screening of family members after detecting FH in an index case and manages hypercholesterolaemia in childhood, thereby preventing premature coronary artery disease.
Endothelial Dysfunction, But Not Structural Atherosclerosis, Is Evident Early in Children With Heterozygous Familial Hypercholesterolemia
Children with heterozygous familial hypercholesterolemia (heFH) are prone to premature atherosclerosis. Vascular endothelial dysfunction may predict increased cardiovascular risk in children with…
Portuguese Familial Hypercholesterolemia Study: presentation of the study and preliminary results.
  • M. Bourbon, Q. Rato
  • Medicine
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
  • 2006
TLDR
Genetic diagnosis enables correct identification of the disease and provides the basis for more aggressive pharmacologic therapeutic interventions to reduce cardiovascular risk in affected individuals.
The Effect of Long-Term Atorvastatin Therapy on Carotid Intima-Media Thickness of Children With Dyslipidemia
TLDR
Treatment with atorvastatin had a beneficial effect on the lipid profile and cIMT progression in children with severe dyslipidemia and resulted in a significantly improved lipid profile.
Detection of familial hypercholesterolemia in a cohort of children with hypercholesterolemia: results of a family and DNA-based screening.
Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia.
Familial hypercholesterolemia in childhood
TLDR
Simvastati n significandy reduced LDL-C, TC, TG, VLDLC and Apoo B levels and was well tolerated in children with FH and there was no evidence off any adverse effect of simvastatis n on growth and pubertal development.
Long-Term Follow-Up of Statin Treatment in a Cohort of Children with Familial Hypercholesterolemia
TLDR
In this large cohort of FH children, the efficacy and tolerability of pravastatin therapy in reallife conditions was demonstrated to be similar to that in randomized controlled studies.
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References

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TLDR
The results showed that simvastatin seems to be an effective and safe medical therapy even in children and adolescents with familial hypercholesterolaemia.
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TLDR
A dose-response relationship was seen, and between-group comparisons showed that results were significantly improved up to a dose of 30 mg/d, and the medication was well tolerated by all patients.
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TLDR
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Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia
TLDR
A clear reduction of LDL cholesterol is shown by plant sterols treatment, however, short-term plant sterol treatment does not improve the endothelial function in FH children.
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TLDR
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TLDR
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