Familial hypercholesterolemia in children

@article{Rodenburg2004FamilialHI,
  title={Familial hypercholesterolemia in children},
  author={Jessica Rodenburg and M. N. Vissers and Albert Wiegman and Mieke D. Trip and HD Bakker and John J. P. Kastelein},
  journal={Current Opinion in Lipidology},
  year={2004},
  volume={15},
  pages={405-411}
}
Purpose of this review This review provides an update on recent advances in the diagnosis and management of children with familial hypercholesterolemia. Recent findings A large cross-sectional cohort study of paediatric familial hypercholesterolemia demonstrated that affected children had a 5-fold more rapid increase of carotid arterial wall intima-media thickness during childhood years than their affected siblings. This faster progression led to a significant deviation in terms of intima-media… 
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    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
  • 2006
TLDR
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Simvastati n significandy reduced LDL-C, TC, TG, VLDLC and Apoo B levels and was well tolerated in children with FH and there was no evidence off any adverse effect of simvastatis n on growth and pubertal development.
Long-Term Follow-Up of Statin Treatment in a Cohort of Children with Familial Hypercholesterolemia
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References

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The effect of low-dose simvastatin in children with familial hypercholesterolaemia: a 1-year observation
TLDR
The results showed that simvastatin seems to be an effective and safe medical therapy even in children and adolescents with familial hypercholesterolaemia.
Treatment of familial hypercholesterolemia in children and adolescents: effect of lovastatin. Canadian Lovastatin in Children Study Group.
TLDR
A dose-response relationship was seen, and between-group comparisons showed that results were significantly improved up to a dose of 30 mg/d, and the medication was well tolerated by all patients.
Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia: a randomized controlled trial.
TLDR
This study in adolescent boys with HeFH confirmed the LDL-C-reducing effectiveness of lovastatin, and comprehensive clinical and biochemical data on growth, hormonal, and nutritional status indicated no significant differences between Lovastatin and placebo over 48 weeks, although further study is required.
Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia
TLDR
A clear reduction of LDL cholesterol is shown by plant sterols treatment, however, short-term plant sterol treatment does not improve the endothelial function in FH children.
The Apolipoprotein ε4 Allele Confers Additional Risk in Children with Familial Hypercholesterolemia
TLDR
It is concluded that the ε4 allele was associated with lower HDL cholesterol levels in an affected sib-pair analysis, which strongly suggests that apoE4 influences HDLolesterol levels in FH children.
Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.
TLDR
Impaired endothelium-dependent dilation is present in children with familial hypercholesterolemia as young as 7 yr of age and the degree of impairment is related to the lipoprotein(a) level.
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