Familial hypercholesterolemia and response to statin therapy according to LDLR genetic background.

@article{Choumerianou2005FamilialHA,
  title={Familial hypercholesterolemia and response to statin therapy according to LDLR genetic background.},
  author={Despoina M Choumerianou and George V. Z. Dedoussis},
  journal={Clinical chemistry and laboratory medicine},
  year={2005},
  volume={43 8},
  pages={793-801}
}
Familial hypercholesterolemia is an autosomal dominant disease defined at the molecular level mainly by the presence of mutations in the low-density lipoprotein receptor gene and is characterized by elevated low-density lipoprotein cholesterol, tendon xanthomas and increased risk of early cardiovascular disease. The type of mutation in the low-density lipoprotein receptor gene has been associated with different phenotype expression and response to statins. Several studies have been undertaken… CONTINUE READING

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