Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies.

@article{Thim2010FamilialHD,
  title={Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies.},
  author={Troels Thim and Mette Kallestrup Hagensen and Ludovic Drouet and Claire Bal dit Sollier and Michel Bonneau and Juan F Granada and Lars Bo Nielsen and William P. Paaske and Hans Erik B\otker and E. Falk},
  journal={EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology},
  year={2010},
  volume={6 2},
  pages={261-8}
}
AIMS A manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. Farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. We aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable. METHODS AND… CONTINUE READING

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