Familial hemophagocytic lymphohistiocytosis associated with disseminated T-cell lymphoma: A report of two siblings

@article{Mache1994FamilialHL,
  title={Familial hemophagocytic lymphohistiocytosis associated with disseminated T-cell lymphoma: A report of two siblings},
  author={Christoph Johannes Mache and Irene Slavc and Christoph Schmid and Gerald Hoefler and Christan Urban and Wolfgang Schwinger and Eva Winter and Wolfgang Hulla and Werner W. Zenz and Wolfgang Holter},
  journal={Annals of Hematology},
  year={1994},
  volume={69},
  pages={85-91}
}
Two siblings with evidence of disseminated T-cell lymphoma at the time of diagnosis of familial hemophagocytic lymphohistiocytosis (FHL) are reported, an association which has not been described previously. The first child with typical clinical and laboratory features of FHL died shortly after admission, before diagnosis could be established. Retrospective analysis of autoptic tissue revealed marked hemophagocytosis as well as morphological and immunohistochemical features suggestive of… CONTINUE READING
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