Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons.

@article{Tottene2002FamilialHM,
  title={Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons.},
  author={Angelita Tottene and Tommaso Fellin and S. Pagnutti and Siro Luvisetto and J{\"o}rg Striessnig and Colin Fletcher and Daniela Pietrobon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 20},
  pages={13284-9}
}
Insights into the pathogenesis of migraine with aura may be gained from a study of human Ca(V)2.1 channels containing mutations linked to familial hemiplegic migraine (FHM). Here, we extend the previous single-channel analysis to human Ca(V)2.1 channels containing mutation V1457L. This mutation increased the channel open probability by shifting its activation to more negative voltages and reduced both the unitary conductance and the density of functional channels in the membrane. To investigate… CONTINUE READING

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