• Chemistry
  • Published 1987

Familial giant cell hepatitis associated with synthesis of 3β,7α-dihydroxy- and 3β,7α,12α-trihydroxy-5-cholenoic acid

@inproceedings{Clayton1987FamilialGC,
  title={Familial giant cell hepatitis associated with synthesis of 3β,7α-dihydroxy- and 3β,7α,12α-trihydroxy-5-cholenoic acid},
  author={Peter E. Clayton and James V. Leonard and Alexander M. Lawson and Kenneth D. R. Setchell and Sanna Andersson and B{\"o}rje Egestad and Jan Sjoevall},
  year={1987}
}
Urinary bile acids from a 3-mo-old boy with cholestatic jaundice were analyzed by ion exchange chromatography and gas chromatography-mass spectrometry (GC-MS). This suggested the presence of labile sulfated cholenoic acids with an allylic hydroxyl group, a conclusion supported by analysis using fast atom bombardment mass spectrometry (FAB-MS). The compounds detected by FAB-MS were separated by thin layer chromatography and high performance liquid chromatography. The sulfated bile acids could be… CONTINUE READING

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