Familial gastrointestinal stromal tumours with germline mutation of the KIT gene

@article{Nishida1998FamilialGS,
  title={Familial gastrointestinal stromal tumours with germline mutation of the KIT gene},
  author={Toshirou Nishida and Seiichi Hirota and Masahiko Taniguchi and Koji Hashimoto and Kouji Isozaki and Harumi Nakamura and Yuzuru Kanakura and Tomoyuki N. Tanaka and Arimichi Takabayashi and Hikaru Matsuda and Yukihiko Kitamura},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={323-324}
}
nature genetics volume 19 august 1998 323 Gastrointestinal stromal tumour (GIST) is the most common mesenchymal tumour of the human gastrointestinal tract. Most GISTs are solitary, and gain-offunction mutations of the KIT protooncogene have been found in these tumours1. We report here a family with multiple GISTs: affected members all have a KIT mutation occurring between the transmembrane and tyrosine kinase domains, which is also the region where mutations have been found in solitary GISTs… CONTINUE READING
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