Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.

@article{Weisgraber1988FamilialDA,
  title={Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.},
  author={Karl Heinrich Weisgraber and Thomas L. Innerarity and Yvonne M. Newhouse and Stephen G. Young and Kay S. Arnold and Ronald M. Krauss and Gloria Lena Vega and Scott M Grundy and Robert W. Mahley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 24},
  pages={
          9758-62
        }
}
Familial defective apolipoprotein (apo) B-100 is a recently described genetic disorder that appears to result from a mutation in the apoB-100 gene. This disorder is characterized by hypercholesterolemia resulting from elevated plasma concentrations of low density lipoprotein LDL. The disorder was first detected in three members of one family. The LDL from affected subjects binds defectively (approximately 30% of normal) to LDL receptors, retarding the clearance of LDL from plasma. In the… CONTINUE READING
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