Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)

@article{Pajukanta2004FamilialCH,
  title={Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)},
  author={P{\"a}ivi Pajukanta and Heidi E Lilja and Janet S. Sinsheimer and Rita M. Cantor and Aldons J. Lusis and Massimiliano Gentile and Xiaoqun Joyce Duan and Aino Soro-Paavonen and Jussi Naukkarinen and Janna Saarela and Markku Laakso and Christian P Ehnholm and Marja-Riitta Taskinen and L. Peltonen},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={371-376}
}
Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% of individuals with premature coronary heart disease. We previously identified a locus linked to FCHL on 1q21–q23 in Finnish families with the disease. This region has also been linked to FCHL in families from other populations as well as to type 2 diabetes mellitus. These clinical entities have several overlapping phenotypic features, raising the… CONTINUE READING
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