Familial combined hyperlipidaemia: under - defined and under - diagnosed?

  title={Familial combined hyperlipidaemia: under - defined and under - diagnosed?},
  author={Anthony S Wierzbicki and Colin A. Graham and Ian S Young and David P. Nicholls},
  journal={Current vascular pharmacology},
  volume={6 1},
Familial combined hyperlipidaemia (FCH) was identified in early genetic studies of populations as a dominant condition associated with mixed hyperlipidaemia and early onset coronary heart disease. Later studies extended the phenotype and noted that this genetic hyperlipidaemia was sensitive to environmental effects. This article reviews the definitions, animal models and genetics of FCH. In contrast to familial hypercholesterolaemia, which is caused by mutations in a limited number of affected… CONTINUE READING