Familial clustering and genetic risk for dementia in a genetically isolated Dutch population.

  title={Familial clustering and genetic risk for dementia in a genetically isolated Dutch population.},
  author={Kristel Sleegers and Gerwin Roks and Jessie Theuns and Yurii S. Aulchenko and Rosa Rademakers and Marc Cruts and Willem A van Gool and Christine van Broeckhoven and Peter Heutink and Ben A. Oostra and John Cornelis van Swieten and Cornelia M van Duijn},
  journal={Brain : a journal of neurology},
  volume={127 Pt 7},
Despite advances in elucidating the genetic epidemiology of Alzheimer's disease and frontotemporal dementia, the aetiology for most patients with dementia remains unclear. We examined the genetic epidemiology of dementia in a recent genetically isolated Dutch population founded around 1750. The series of 191 patients ascertained comprised 122 probable Alzheimer's disease patients with late onset and 17 with early onset, and 22 with possible Alzheimer's disease. It further included 10 patients… CONTINUE READING


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