Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

@article{Nikkil2009FamilialBC,
  title={Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function},
  author={Jenni Nikkil{\"a} and Kara A Coleman and David Morrissey and Katri Pylk{\"a}s and Hannele Erkko and Troy E. Messick and S-M Karppinen and Anna Amelina and Robert Winqvist and Roger A. Greenberg},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={1843-1852}
}
Germline mutations in two major susceptibility genes, BRCA1 and BRCA2, account for nearly 20% of familial breast cancers. A majority of the remaining genetic factors involved in heritable breast cancer susceptibility are, however, unknown. Recently, a new BRCA1-interacting protein, receptor associated protein 80 (RAP80), was identified. RAP80 plays an important role in BRCA1-mediated DNA damage responses (DDRs) by recruiting BRCA1 to DNA double-strand breaks (DSBs). A comprehensive screening of… CONTINUE READING
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