Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease

  title={Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease},
  author={Piet A. Brandt and R. Alexandra Goldbohm},
  journal={The Lancet},

Familial Breast Cancer: Scope for More Susceptibility Genes?

The data suggest that familial aggregation of breast cancer is mainly due to heritable causes, and the remaining majority offers a challenge to new genomic approaches.

A constant risk for familial breast cancer? A population-based family study

Incidence of familial breast cancer in first-degree relatives may increase to a high and constant level by a predetermined age that is specific to each family, which appears inconsistent with accepted theories of malignant transformation.

Attributable risks for familial breast cancer by proband status and morphology: A nationwide epidemiologic study from Sweden

The data show that the familial PAF of breast cancer among a 0–66‐year‐old population of daughters was 7% and independent of the morphologic type, and if contribution from the paternal side was allowed for, the PAF would be 11%.

Impact of familial risk and mammography screening on prognostic indicators of breast disease among women from the Ontario site of the Breast Cancer Family Registry

Screening mammography may be effective for women with a first-degree family history of breast cancer, irrespective of level of familial risk, and prognostic features of invasive cancers and BBD are compared.

Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family Registry

Clinical management should not depend on family history of breast cancer, as it is not associated with all-cause mortality after breast cancer diagnosis for women without a known germline mutation in BRCA1 or BRCa2.

Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study.

  • A. ReinerJ. Sisti J. Bernstein
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2018
The WECARE study demonstrated the importance of breast cancer family history on contralateral breast cancer risk, even for noncarriers of deleterious BRCA1/2 mutations, as well as the need to use detailed family histories to guide treatment and future screening decisions for young women with breast cancer.

Familial relative risks for breast cancer by pathological subtype: a population-based cohort study

FRR for breast cancer was significantly increased for both ER-negative and ER-positive disease, and including receptor status in conjunction with genetic status may aid risk prediction in women with a family history.

Family history of cancer and risk of breast cancer in the Black Women’s Health Study

Findings indicate a strong familial relationship for breast cancer in African American women and the associations with family history of colon cancer and leukemia warrant further investigation.

Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry

This wide variation in risks for relatives based on tumour characteristics could be of clinical value, help discover new breast cancer susceptibility genes and be an advance on the current clinical practice of using ER and PR as pathology-based predictors of familial and possibly genetic risks.



Family history, age, and risk of fatal breast cancer.

In the authors' data, family history is strongly predictive of early fatal breast cancer, particularly when the disease is diagnosed before age 50 in the relative, and women with a family history of early breast cancer should receive special instructions regarding mammography and early detection.

Effect of family history, body-fat distribution, and reproductive factors on the risk of postmenopausal breast cancer.

The combined effect of family history and anthropometric and reproductive factors on the risk of breast cancer in postmenopausal women and the waist-to-hip ratio was examined to determine whether known risk factors for breast cancer are modified by a reported family history at the time of entry into the study.

A breast cancer case—control study in Girona, Spain. Endocrine, familial and lifestyle factors

Hormonal changes in the years following menarche may be relevant to breast cancer risk and the roles of menstrual period length and acne during adolescence should be further explored.

Risk factors for breast cancer in Chinese women in Shanghai.

This study demonstrates a clear beneficial effect on breast cancer risk of lactation in a population characterized by a long cumulative duration of nursing in the majority of women, and supports several other recent reports of a residual and beneficial effect of parity on Breast cancer risk after controlling for age at first full term pregnancy.

Risk factors for female breast cancer. A hospital-based case-control study in Madras, India.

Nulliparity was found to be a risk factor in premenopausal women only and the relative risk increased with age at marriage and age at first birth, while single women had higher risk than married women.

The pattern of risk factors for breast cancer in a southern France population. Interest for a stratified analysis by age at diagnosis.

A hospital-based case-control study was conducted in Southern France to assess the pattern of established risk factors for breast cancer and to examine its variation according to age at diagnosis, which suggests a complex involvement of the reproductive and sociodemographic features with the various stages of the 'natural history' of breast cancer.

Canadian National Breast Screening Study: 1. Breast cancer detection and death rates among women aged 40 to 49 years.

Screening with yearly mammography and physical examination of the breasts detected considerably more node-negative, small tumours than usual care, but it had no impact on the rate of death from breast cancer up to 7 years' follow-up from entry.

Oral contraceptives and risk of breast cancer

The risk of breast cancer was not increased by use of oral contraceptives for long periods before the first pregnancy or by starting use at a young age, and Parity, age at menarche, family history of Breast cancer, or history of benign breast disease did not modify the effect of oral contraceptive on breast‐cancer risk.