Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease

@article{Brandt2001FamilialBC,
  title={Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease},
  author={Piet A. Brandt and R. Alexandra Goldbohm},
  journal={The Lancet},
  year={2001},
  volume={358},
  pages={1389-1399}
}
Familial Breast Cancer: Scope for More Susceptibility Genes?
TLDR
The data suggest that familial aggregation of breast cancer is mainly due to heritable causes, and the remaining majority offers a challenge to new genomic approaches.
Impact of familial risk and mammography screening on prognostic indicators of breast disease among women from the Ontario site of the Breast Cancer Family Registry
TLDR
Screening mammography may be effective for women with a first-degree family history of breast cancer, irrespective of level of familial risk, and prognostic features of invasive cancers and BBD are compared.
Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family Registry
TLDR
Clinical management should not depend on family history of breast cancer, as it is not associated with all-cause mortality after breast cancer diagnosis for women without a known germline mutation in BRCA1 or BRCa2.
Familial relative risks for breast cancer by pathological subtype: a population-based cohort study
TLDR
FRR for breast cancer was significantly increased for both ER-negative and ER-positive disease, and including receptor status in conjunction with genetic status may aid risk prediction in women with a family history.
Family history of cancer and risk of breast cancer in the Black Women’s Health Study
TLDR
Findings indicate a strong familial relationship for breast cancer in African American women and the associations with family history of colon cancer and leukemia warrant further investigation.
A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
TLDR
Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.
Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry
TLDR
This wide variation in risks for relatives based on tumour characteristics could be of clinical value, help discover new breast cancer susceptibility genes and be an advance on the current clinical practice of using ER and PR as pathology-based predictors of familial and possibly genetic risks.
Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women
TLDR
A family history of cancers other than breast may influence the risk of breast cancer, and associations may differ by subtype.
Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study
TLDR
A strong family history of breast cancer is associated with an increased use of systemic therapy in early-onset patients and it may impair survival of very young patients and patients treated without adjuvant chemotherapy.
Association of Family History with the Development of Breast Cancer: A Cohort Study of 129,374 Women in KoGES Data
TLDR
Premenopausal women with a maternal history of breast cancer are of particular concern, and intensive screening and risk-reducing strategies should be considered for this vulnerable subpopulation.
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TLDR
In the authors' data, family history is strongly predictive of early fatal breast cancer, particularly when the disease is diagnosed before age 50 in the relative, and women with a family history of early breast cancer should receive special instructions regarding mammography and early detection.
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TLDR
The combined effect of family history and anthropometric and reproductive factors on the risk of breast cancer in postmenopausal women and the waist-to-hip ratio was examined to determine whether known risk factors for breast cancer are modified by a reported family history at the time of entry into the study.
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Hormonal changes in the years following menarche may be relevant to breast cancer risk and the roles of menstrual period length and acne during adolescence should be further explored.
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TLDR
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TLDR
Screening with yearly mammography and physical examination of the breasts detected considerably more node-negative, small tumours than usual care, but it had no impact on the rate of death from breast cancer up to 7 years' follow-up from entry.
Oral contraceptives and risk of breast cancer
TLDR
The risk of breast cancer was not increased by use of oral contraceptives for long periods before the first pregnancy or by starting use at a young age, and Parity, age at menarche, family history of Breast cancer, or history of benign breast disease did not modify the effect of oral contraceptive on breast‐cancer risk.
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