Familial amyotrophic lateral sclerosis: Features of multisystem degeneration

  title={Familial amyotrophic lateral sclerosis: Features of multisystem degeneration},
  author={Junichi Tanaka and Haruomi Nakamura and Yoshikatsu Tabuchi and Kazuro Takahashi},
  journal={Acta Neuropathologica},
Two sibling cases of familial amyotrophic lateral sclerosis (ALS) revealed degerneration usually associated with other systemic degenerative disorders. The changes in the 41-year-old sister were compatible with those reported in other familial ALS cases affecting the upper and lower motor neurons, posterior columns, and spinocerebellar tracts. The 45-year-old sister revealed more wide-spread degenerative changes involving not only motor neuron systems, but also proprioceptive, general somatic… CONTINUE READING