Familial amyloid polyneuropathy

@article{Koeppen1985FamilialAP,
  title={Familial amyloid polyneuropathy},
  author={A. Koeppen and E. Mitzen and M. B. Hans and S. Peng and R. O. Bailey},
  journal={Muscle \& Nerve},
  year={1985},
  volume={8}
}
Amyloid fibrils were isolated from the myocardium of two patients with familial amyloid polyneuropathy. The solubilized amyloid fibril whole protein shared immunologic determinants with normal human serum prealbumin (transthyretin), but revealed subtle differences on immunoelectrophoresis and radial immunodiffusion. On sodium dodecyl sulfate‐polyacrylamide gel electrophoresis, amyloid fibril whole protein was resolved into numerous bands that reacted with antitransthyretin on immunoblots. The… Expand
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