Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease.

@article{Abdelmalek2006FamilialAO,
  title={Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease.},
  author={Manal F. Abdelmalek and Chen Liu and Jonathan J Shuster and David R. Nelson and Nabih R. Asal},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2006},
  volume={4 9},
  pages={1162-9}
}
BACKGROUND & AIMS An association between nonalcoholic fatty liver disease (NAFLD) and the insulin resistance (IR) syndrome exists. Familial clustering of IR may support a genetic predisposition to NAFLD or cryptogenic cirrhosis (CC). METHODS Patients with NAFLD (n = 20) and healthy controls (n = 20) matched for age, sex, and body mass index with at least 4 living relatives and 2 generations of lineage participated in a familial aggregation study. A medical history was obtained from each… CONTINUE READING

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