Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families

@article{Palmer2000FamilialAA,
  title={Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families},
  author={Lyle John Palmer and Paul R. Burton and Alan L. James and Arthur William Musk and William O C M Cookson},
  journal={European Journal of Human Genetics},
  year={2000},
  volume={8},
  pages={853-860}
}
Asthma is a common, genetically complex human disease. Elevated serum immunoglobulin E (IgE) levels, elevated blood eosinophil counts, variably reduced spirometric measures and increased airway responsiveness (AR) are physiological traits which are characteristic of asthma. We investigated the genetic and environmental components of variance of serum total and specific IgE levels, blood eosinophil counts, the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), and AR… CONTINUE READING

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